Chung-Chiun Liu

Professor Emeritus, Chemical Engineering Director Emeritus of EDC, Electronics Design Center
Develops chemical and biomedical sensors for single-use, cost-effective measurements
Office: 112 Bingham Phone Number: (216) 368-2935 Fax Number: (216) 368-8738 Email: chung-chiun.liu@case.edu

Education

Ph.D., Chemical Engineering, Case Western Reserve University, 1968
Post Graduate, Bioelectronics, Case Western Reserve University, 1968
M.S., Chemical Engineering, California Institute of Technology, 1962
B.S., Chemical Engineering, National Cheng Kung University, Taiwan , 1959

Awards and Recognitions

2016, Gold Medal Award (Highest honor given by CAA), Case Aluni Association (CAA)

Research Interests

Electrochemical science and technology, microfabrication processes, chemical and biochemical sensor technology

Publications

Dai, Y., Xu, X., Somoza, R., Welter, J., Caplan, A., & Liu, C. (2020). An Integrated Multi-Function Heterogeneous Biochemical Circuit for High-Resolution Electrochemistry-Based Genetic Analysis. Angewandte Chemie - International Edition, 59 (46), 20545-20551.
Ying, Z., Zhang, Y., Janyasupab, M., & Liu, C. (2020). A Bio-Conjugation Chemistry Strategy to Self-Immobilize Antibodies with ZIF-90-ZnO-MoS 2 Nanohybrid for Exosome Markers Analysis. ECS Meeting Abstracts, MA2020-01 (35), 2462-2462.
Janyasupab, M., Asavakijthananont, N., Zhang, Y., Chanlek, N., Chio-Srichan, S., Surareungchai, W., & Liu, C. (2020). Rapid Evaluation Method of Post Dialysate Urea Nitrogen Measurement for Chronic Kidney Disease Patients By Using Non-Enzymatic N-Doped Carbon Supported Nickel Based Biosensor. ECS Meeting Abstracts, MA2020-01 (27), 2028-2028.
Ying, Z., Feng, L., Ji, D., Zhang, Y., Cheng, W., Dai, Y., Janyasupab, M., Li, X., Wen, W., & Liu, C. (2020). Electrochemical Microsensors: Phase-Regulated Sensing Mechanism of MoS 2 Based Nanohybrids toward Point-of-Care Prostate Cancer Diagnosis (Small 18/2020). Small, 16 (18).
Xu, X., Jin, T., Dai, Y., & Liu, C. (2020). Surpassing the detection limit and accuracy of the electrochemical DNA sensor through the application of CRISPR Cas systems. Biosensors and Bioelectronics, 155
Ying, Z., Feng, L., Ji, D., Zhang, Y., Cheng, W., Dai, Y., Janyasupab, M., Li, X., Wen, W., & Liu, C. (2020). Phase-Regulated Sensing Mechanism of MoS 2 Based Nanohybrids toward Point-of-Care Prostate Cancer Diagnosis. Small, 16 (18).
Hunter, G., Akbar, S., Bhansali, S., Daniele, M., Erb, P., Johnson, K., Liu, C., Miller, D., Oralkan, O., Hesketh, P., Manickam, P., & Vander Wal, R. (2020). Editors' Choice—Critical Review—A Critical Review of Solid State Gas Sensors. Journal of The Electrochemical Society, 167 (3).
Liu, C., Deng, S., Fujino, Y., Gong, Y., Cheng, C., Fan, Z., Qian, Z., Huang, J., Ni, Q., Luo, C., & Yu, X. (2020). Lewis antigen‑negative pancreatic cancer: An aggressive subgroup.. International journal of oncology.
Dai, Y., Xu, X., & Liu, C. (2020). Immunoglobulin G-Based Steric Hindrance Assay for Protein Detection. ACS Sensors, 5 (1), 140-146.
Dai, Y., Abbasi, K., Bandyopadhyay, S., & Liu, C. (2019). Dynamic Control of Peptide Strand Displacement Reaction Using Functional Biomolecular Domain for Biosensing. ACS Sensors, 4 (8), 1980-1985.
Huang, J., Dai, Y., Singewald, K., Liu, C., Saxena, S., & Zhang, H. (2019). Effects of MnO2 of different structures on activation of peroxymonosulfate for bisphenol A degradation under acidic conditions. Chemical Engineering Journal, 370 , 906-915.
Dai, Y., & Liu, C. (2019). Recent Advances on Electrochemical Biosensing Strategies toward Universal Point-of-Care Systems. Angewandte Chemie - International Edition.
Xu, X., Ji, D., Zhang, Y., Gao, X., Xu, P., Li, X., Liu, C., & Wen, W. (2019). Detection of Phenylketonuria Markers Using a ZIF-67 Encapsulated PtPd Alloy Nanoparticle (PtPd@ZIF-67)-Based Disposable Electrochemical Microsensor. ACS Applied Materials & Interfaces, 11 (23), 20734-20742.
Sui, Y., Dai, Y., Liu, C., Sankaran, R., & Zorman, C. (2019). A New Class of Low-Temperature Plasma-Activated, Inorganic Salt-Based Particle-Free Inks for Inkjet Printing Metals. Advanced Materials Technologies.
Sui, Y., Dai, Y., Liu, C., Sankaran, R., & Zorman, C. (2019). A New Class of Low-Temperature Plasma-Activated, Inorganic Salt-Based Particle-Free Inks for Inkjet Printing Metals. Advanced Materials Technologies.
Sui, Y., Dai, Y., Liu, C., Sankaran, R., & Zorman, C. (2019). A New Class of Low-Temperature Plasma-Activated, Inorganic Salt-Based Particle-Free Inks for Inkjet Printing Metals. Advanced Materials Technologies.
Dai, Y., Chiu, L., Chen, Y., Qin, S., Wu, X., & Liu, C. (2019). Neutral Charged Immunosensor Platform for Protein-based Biomarker Analysis with Enhanced Sensitivity. ACS Sensors, 4 (1), 161-169.
Huang, J., Dai, Z., Liu, C., & Zhang, H. (2019). Effects of MnO2 of different structures on activation of peroxymonosulfate for bisphenol A degradation under acidic conditions. Chem. Eng. J., 370 , 906-915.
Dai, Y., Huang, J., Zhang, H., & Liu, C. (2019). Metal Oxides Nanoparticles based Redox-like Reaction as an Ultrasensitive Direct Electrochemical Biosensing Strategy through Electrostatic Interactions. Chemistry - A European Journal, In Review
Huang, J., Dai, Y., Liu, C., & Zhang, H. (2019). Effects of Second Metal Oxides on Surface-Mediated Reduction of Contaminants by Fe(II) with Iron Oxide. ACS Earth Space Chem, 3 , 680-687.
Liu, C., Chiu, L., Sui, Y., Dai, Q., Penumutchu, S., Jain, N., Dai, L., Zorman, C., Tolbert, B., Sankaran, R., & Liu, C. (2019). Nanoparticle based simple electrochemical biosensor platform for profiling of protein-nucleic acid interactions. Talanta, 195 , 46-54.
Dai, Y., Huang, J., Zhang, H., & Liu, C. (2019). Highly sensitive electrochemical analysis of tunnel structured MnO2 nanoparticle-based sensors on the oxidation of nitrite. Sensors and Actuators B: Chemical, 281 , 746-750.
Liu, C., Chiu, L., Chen, Y., Qin, S., Wu, X., & Liu, C. (2019). Neutral charged immunosensor platform for protein-based biomarker analysis with enhance sensivity. ACS Sensors, 4.1 , 161-169.
Dai, Y., Wang, C., Chiu, L., Abbasi, K., Tolbert, B., Sauv�, G., Yen, Y., & Liu, C. (2018). Application of bioconjugation chemistry on biosensor fabrication for detection of TAR-DNA binding protein 43. Biosensors and Bioelectronics, 117 , 60-67.
Bai, S., Tian, K., Fu, H., Feng, Y., Luo, R., Li, D., Chen, A., & Liu, C. (2018). Novel a-Fe 2 O 3 /BiVO 4 heterojunctions for enhancing NO 2 sensing properties. Sensors and Actuators, B: Chemical, 268 , 136-143.
Yao, J., Wang, Y., Dai, Y., & Liu, C. (2018). Bioconjugated, Single-Use Biosensor for the Detection of Biomarkers of Prostate Cancer. ACS Omega, 3 (6), 6411-6418.
Bai, S., Tian, Y., Zhao, Y., Fu, H., Tang, P., Luo, R., Li, D., Chen, A., & Liu, C. (2018). Construction of NiO@ZnSnO3 hierarchical microspheres decorated with NiO nanosheets for formaldehyde sensing. Sensors and Actuators, B: Chemical, 259 , 908-916.
Bai, S., Tian, K., Tian, Y., Guo, J., Feng, Y., Luo, R., Li, D., Chen, A., & Liu, C. (2018). Synthesis of Co3O4/TiO2 composite by pyrolyzing ZIF-67 for detection of xylene. Applied Surface Science, 435 , 384-392.
Dai, Y., Molazemhosseini, A., Abbasi, K., & Liu, C. (2018). A Cuprous Oxide Thin Film Non-Enzymatic Glucose Sensor Using Differential Pulse Voltammetry and Other Voltammetry Methods and a Comparison to Different Thin Film Electrodes on the Detection of Glucose in an Alkaline Solution. Biosensors Journal, 8 (1).
Liu, C., Abbasi, K., DePietro, M., Butler, S., & Liu, C. (2018). Advanced fabrication of biosensor on detection of glypican -1 using S-acetylmercaptosuccinic anhydride (SAMSA) medication of antibody. Scienfic Reports, 8 , 13541.
Bai, S., Fu, H., Shu, X., Luo, R., Chen, A., Li, D., & Liu, C. (2018). NiO hierarchical hollow microspheres doped Fe to enhance triethylamine sensing properties. Materials Letters, 210 , 305-308.
Huang, J., Zhong, S., Dai, Y., Liu, C., & Zhang, H. (2018). Effect of Phase Structure of MnO2 on the Oxidation Reactivity toward Bisphenol A Degradation. Environ. Sci. Technol., 52 (19), 11309-11318.
Liu, C., Magagnin, L., Vena, P., & Liu, C. (2017). A single-use nonezymatic glucose biosensor based on CuOnanoparticles ink printed on thin gold electrode by microplotter technology. J. of Electroanalytical Chemistry, 789 , 50-57.
Bai, S., & Liu, C. (2017). A flexible sensor based on polyaniline hybrite using ZnO as. .
Dai, Y., Molazemhosseini, A., & Liu, C. (2017). A Single-Use, In Vitro Biosensor for the Detection of T-Tau Protein, A Biomarker of Neuro-Degenerative Disorders, in PBS and Human Serum Using Differential Pulse Voltammetry (DPV). Biosensors, 7 (1), 10.
Sun, J., Shu, X., Tian, Y., Tong, Z., Bai, S., Luo, R., Li, D., & Liu, C. (2017). Facile preparation of polypyrrole-reduced graphene oxide hybrid for enhancing NH3 sensing at room temperature. Sensors and Actuators, B: Chemical, 241 , 658-664.
Molazemhosseini, A., Magagnin, L., Vena, P., & Liu, C. (2017). Single-use nonenzymatic glucose biosensor based on CuO nanoparticles ink printed on thin film gold electrode by micro-plotter technology. Journal of Electroanalytical Chemistry, 789 , 50-57.
Quan, L., Sun, J., Bai, S., Luo, R., Li, D., Chen, A., & Liu, C. (2017). A flexible sensor based on polyaniline hybrid using ZnO as template and sensing properties to triethylamine at room temperature. Applied Surface Science, 399 , 583-591.
Bai, S., Liu, J., Guo, J., Luo, R., Li, D., Song, Y., Liu, C., & Chen, A. (2017). Facile preparation of SnO 2 /NiO composites and enhancement of sensing performance to NO 2. Sensors and Actuators, B: Chemical, 249 , 22-29.
Bai, S., Guo, J., Shu, X., Xiang, X., Luo, R., Li, D., Chen, A., & Liu, C. (2017). Surface functionalization of Co 3 O 4 hollow spheres with ZnO nanoparticles for modulating sensing properties of formaldehyde. Sensors and Actuators, B: Chemical, 245 , 359-368.
Dai, Y., & Liu, C. (2017). Detection of 17 ß-Estradiol in Environmental Samples and for Health Care Using a Single-Use, Cost-Effective Biosensor Based on Differential Pulse Voltammetry (DPV). Biosensors Journal, 7 (2).
Cheng, W., Liu, Y., Zhang, Y., Fang, J., Xu, P., Xu, J., Li, X., Liu, C., & Wen, W. (2017). Highly effective and specific way for the trace analysis of carbaryl insecticides based on Au 42 Rh 58 alloy nanocrystals. Journal of Materials Chemistry A, 5 (15), 7064-7071.
Molazemhosseini, A., Magagnin, L., Vena, P., & Liu, C. (2016). Single-Use Disposable Electrochemical Label-Free Immunosensor for Detection of Glycated Hemoglobin (HbA1c) Using Differential Pulse Voltammetry (DPV). Sensors, 16 (7), 1024.
Liu, C., Li, F., Chaube, R., Laskowski, D., & Liu, C. (2016). A single use biosensor for the detection of nitric oxide at ppb and sub-uM level in gas-and liquid-phase media. current Biomarkers, 6 , 92-100.
Molazemhosseini, A., Magagnin, L., Vena, P., & Liu, C. (2016). Single-Use Disposable Electrochemical Label-Free Immunosensor for Detection of Glycated Hemoglobin (HbA1c) Using Differential Pulse Voltammetry (DPV). Sensors [14248220], 16 (7).
Bai, S., Du, L., Sun, J., Luo, R., Li, D., Chen, A., & Liu, C. (2016). Preparation of reduced graphene oxide/Co 3 O 4 composites and sensing performance to toluene at low temperature. RSC Advances [20462069], 6 (65), 60109-60116.
Cao, L., Qian, Z., Huang, Y., Cao, J., Jiao, X., Liu, C., Zhang, G., & Lu, Z. (2015). [Synthesis and Spectroscopic Study of a Chemosensor for Naked Eye Recognition of Cu2+ and Hg2+].. Guang pu xue yu guang pu fen xi = Guang pu, 35 (7), 1797-801.
Liu, C. (2015). Detection of lysyl oxidase-like 2 (LOXL2), a biomarker of metastasis from breast cancers using human blood samples. Recent Patents on Biomarkers, 5 , 93-100.
Auletta, J., Eid, S., Wuttisarnwattana, P., Silva, G., Metheny, L., Keller, M., Guardia-Wolff, R., Liu, C., Wang, F., Bowen, T., Lee, Z., Solchaga, L., Ganguly, S., Tyler, M., Wilson, D. L., & Cooke, K. L. (2015). Human mesenchymal stromal cells attenuate graft-versus-host disease and maintain graft-versus-leukemia activity following experimental allogeneic bone marrow transplantation.. Stem cells (Dayton, Ohio), 33 (2), 601-14.
Zhang, Y., Han, T., Zhu, L., Fang, J., Wang, P., Xu, J., Xu, P., Li, X., & Liu, C. (2015). Pt35Cu65 nanoarchitecture: a highly durable and effective electrocatalyst towards methanol oxidation. NANOTECHNOLOGY, 26 (13), -.
Kung, C., Lin, P., Xue, Y., Akolkar, R. N., Dai, L. N., Yu, X. N., & Liu, C. N. (2014). Three dimensional graphene foam supported platinum–ruthenium bimetallic nanocatalysts for direct methanol and direct ethanol fuel cell applications. Journal of Power Sources, 256 , 329–335.
Lee, S., Janyasupab, M., Liu, C., & Sankaran, R. (2013). Fabrication of Ir nanoparticle-based biosensors by plasmaelectrochemical reduction for enzyme-free detection of hydrogen peroxide. CATALYSIS TODAY, 211 , 137-142.
Liu, C. (2013). Preparation and characterization of three dimensional graphene foam supported platinum-ruthenium bimetallic nanocatalysts for hydrogen peroxide based electrochemical biosensors. .
Liu, C. (2013). Mechanism Enhancing Gas Sensing And First-principle Calculation of Al-doped ZnO Nanostructure. .
Liu, C. (2013). Bimetallic Catalyst of PtIr Nanoparticles with High Electrocatalytic Ability for Hydrogen Peroxide Oxidation. .
Liu, C. (2013). Platinum-decorated gold nanoparticles for non-enzymatic glucose biosensing”,. .
Liu, C. (2013). Bimetallic Pt–M (M = Cu, Ni, Pd, and Rh) nanoporous for H2O2 based amperometric biosensors”. .
Liu, C. (2012). Bimetallic PtM (M=Pd Ir) nanoparticle decorated multi-walled nanitube enzyme-free mediator-less amperometric sensor for H2O2. .
Liu, C. (2012). Effect ofcalcination temperature on NO2sensing properties for quantum size ZnO crystals”. .
Liu, C. (2012). Improvement of amperometric biosensor performance for H2O2 detection based on. .
Liu, C. (2012). Three Dimensional PtRh Alloy Porous Nanostructures: Tuning the Atomic Composition and Controlling the Morphology for the Application of Direct Methanol Fuel Cells,". .
Liu, C. (2012). Detection of alpha-methylacyl-CoA racemase (AMACR), a biomarker of prostate cancer, in patient blood samples using a nanoparticle electrochemical biosensor”. .
Liu, C. (2012). Fabrication and applicationof amperometric glucose biosensor based on a novel PtPd bimetallic nanoparticle decorated multi-walled carbon nanotube catalyst. .
Liu, C. (2012). Low-temperature hydrothermal synthesis of WO3 nanorods and their sensing properties for NO2. .
Liu, C. (2012). Bimetallic platinum based catalysts for biosensors and energy storage applications. .
Liu, C. (2012). Development of an Electrochemical Based Aspartate Aminotransferase Nanoparticle Ir-C Biosensor for Screening of Liver Diseases”. .
Liu, C. (2012). Gas sensing properties of quantum-sized ZnO nanoparticles for NO2. .
Liu, C. (2012). Pt-Au core/shell nanorods: preparation and applications as electrolysts for fuel cells”. .