Systems Modeling & Complex Systems Biology

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At Case Western Reserve, we’re conducting interdisciplinary research that combines experimental, computational or mathematical disciplines so faculty and students can better understand complex biological systems. We’re discovering networks involved in human disease and developing new technologies for different treatments.

Researchers are observing the essential patterns of life through the evolution of organisms and species to form complex system models. For example, our researchers have found that a genetic process among many species of rodents could have significant implications about sex determination. 

We’re analyzing the Sry gene, or mammalian gene, which is the sex-determining region Y protein. This protein is involved in male sexual development, which is usually determined by the chromosomes an individual has.

By continuing to explore the effects of this gene, researchers can expand their understanding of human evolution and genetics.

Faculty who conduct research in Systems Modeling & Complex Systems Biology

Evren Gurkan Cavusoglu

Associate Professor, Department of Electrical, Computer and Systems Engineering
Develops dynamical models of biological systems to help improve treatment of complex diseases

Behnam Malakooti

Professor, Department of Electrical, Computer and Systems Engineering
Designs & develops models for industrial, operations, production/manufacturing systems, asymmetric risk analysis & predictions, decision making/behaviour types, artificial neural networks, interactive models, and multiple objective optimization.